As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16744-81-3, name is 4-Methoxypicolinaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
2. (R SS2-[4-(4-METHOXYPYRIDIN-2-YL) BUT-2-YL]-3H-I MIDAZO [4. S-B] PYRID INE; A solution of 7.2 g of tributyl-{1-(3H-imidazo [4,5-b] PYRIDIN-2-YL)-PROPYL}-PHOSPHONIUM chloride (compound A2) in tetrahydrofurane is added to a suspension of 720 mg of sodium hydride (60percent strength suspension in paraffin) in 180 ml of tetrahydrofurane. After 15 min stirring, a solution of 0.500 g of 4-methoxypyridine- 2-carbaldehyde (Ashimori et AL., Chem. Pharm. Bull. 38,2446-2458 (1990) ) in tetrahydrofurane is added dropwise and the reaction mixture is heated at 80°C for 6 h. The mixture is then evaporated to dryness and the resulting residue chomatographed on silica gel using DICHLOROMETHANE/METHANOL 20: 1 to give 3.58 g of a colorless, amorpheous solid, which is dissolved as obtained in 200 ml of methanol. 2.9 ml of trifluoracetic acid and 788 mg of palladium on active carbon (10percent Pd) are added and the suspension is stirred at room temperature for 2.5 d under hydrogen atmosphere. Then the catalyst is filtered off and the reaction mixture is concentrated to dryness. After chromatographical purification of the residue on silica gel (DICHOROMETHANE/METHANOL 10: 1 to 5: 1) and evaporation of the eluents, 1.4 g of the title compound are obtained as an oil. MS: 283.1 (MH+). TLC: Rf = 0.48 (DICHLOROMETHANE/METHANOL 10: 1).
With the rapid development of chemical substances, we look forward to future research findings about 16744-81-3.
Reference:
Patent; ALTANA PHARMA AG; WO2005/30768; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem