Reference of 117846-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.117846-58-9, name is 2,6-Dibromo-3,5-dimethylpyridine, molecular formula is C7H7Br2N, molecular weight is 264.95, as common compound, the synthetic route is as follows.
To a stirred anhydrous THF solution of 4 (3.22 g,12.15 mmol) was added dropwise a 2.4 mol L-1 n-BuLi inhexane solution (5.57 mL, 13.37 mmol) at 195 K under argonatmosphere. Stirring continued for 0.5 h at 195 K; a solutionof (2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene(4.90 g, 13.37 mmol) in THF was added and the reactionmixture was stirred for 1 h at this temperature. The reactionwas quenched by addition of water. After being extractedwith dichloromethane, the organic layer was washed withwater, and dried over anhydrous Na2SO4. The crude productwas purified by column chromatography on Al2O3 usingpetroleum ether as eluent to afford 6 (1.96 g, 28%) as a whitesolid. m.p. 86-87 C; 1H NMR (400 MHz, CDCl3) d 1.83(s, 3H, -CH3), 2.00 (s, 3H, -CH3), 2.29 (s, 3H, -CH3), 7.10(s, 1H, thiophene-H), 7.25 (t, 2H, J 8.0 Hz, benzene-H), 7.33 (t, 2H, J 8.0 Hz, benzene-H, pyridine-H), 7.48 (d, 2H,J 4.0 Hz, benzene-H).
The chemical industry reduces the impact on the environment during synthesis 117846-58-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Liao, Guanming; Xue, Dandan; Zheng, Chunhong; Wang, Renjie; Pu, Shouzhi; Journal of the Brazilian Chemical Society; vol. 27; 11; (2016); p. 1989 – 1997;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem