A new synthetic route of 1124-64-7

The synthetic route of 1124-64-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1124-64-7, name is 1-Butylpyridinium Chloride, the common compound, a new synthetic route is introduced below. 1124-64-7

General procedure: A mixture of pyridine (0.80g, 10mmol) and bromoethane (1.30g, 12mmol) was stirred ar rt for 43h, then the mixture was washed with ether twice and treated with active charcoal for 12h by stirring. After removing active charcoal by filtration and washed with ether, the filtrate was dried under reduced pressure at rt to give 1-ethylpyridin-1-ium bromide (0.60g, 3.2mmol) in 32% yield. Mp 120C, 1H NMR (500MHz, ppm, CDCl3 J=Hz) delta 1.75 (3H, t, J=7.5), 5.10 (2H, q, J=7.5), 8.15 (2H, t, J=7), 8.53 (1H, s), 9.63 (2H, d, J=6.5); 13C NMR (125MHz, ppm, CDCl3 J=Hz) delta 17.37, 57.12, 57.39, 128.48, 128.64, 144.74, 144.92, 145.08, 145.60. A mixture of 1-ethylpyridin-1-ium bromide (150mg, 0.80mmol) and ammonium cetyl-PEG10 sulfate [20] (624mg, 0.80mmol) in dichloromethane (CH2Cl2) (8.0ml) was stirred at rt for 24h to form the precipitate of ammonium bromide (NH4Br). The precipitate was removed by filtration and the extract was diluted with CH2Cl2 and cooled to-25C to form the precipitate of NH4Br which was removed by filtration. This process was repeated several times until no more precipitate was formed. The resulting filtrate was dried by lyophilization to give 666mg (0.77mmol) of PYET in 96% yield

The synthetic route of 1124-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kadotani, Shiho; Nokami, Toshiki; Itoh, Toshiyuki; Tetrahedron; vol. 75; 4; (2019); p. 441 – 447;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem