As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58553-48-3, name is 5-(Hydroxymethyl)picolinonitrile, molecular formula is C7H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C7H6N2O
Example 3A; 5-Formyl-2-pyridinecarbonitrile 1.04 g (8. 2 mmol) oxalylchloride are dissolved in 8 ml dichloromethane. At-78C, 1.28 g (16.4 mmol) dimethylsulfoxide are added dropwise. The solution is stirred at-78C for 20 minutes, then 1 g (7.46 mmol) of the compound of Example 2A, dissolved in 7 ml dichloromethane, is added, and stirring at-78C is continued for another 2 hours. 3.4 g (33.6 mmol) triethylamine are then added dropwise, and after warming up to room temperature, the mixture is purified by column chromatography (silica, eluent: cyclohexane to cyclohexane/ethyl acetate 2: 1). Yield: 0.76 g (77% of th.) Mp.: 80-82C HPLC (method 4): Rt = 2.13 min MS (ESIpos): m/z = 133 (M+H) + ‘H-NMR (400 MHz, DMSO-d6) : 8 = 10. 18 (s, 1H), 9.21 (m, 1H), 8.49 (m, 1H), 8.27 (m, 1H) ppm.
With the rapid development of chemical substances, we look forward to future research findings about 58553-48-3.
Reference:
Patent; BAYER HEALTHCARE AG; WO2005/82863; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem