Reference of 915107-31-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate, molecular formula is C8H8ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of 6-chloro-5-methoxy-nicotinic acid methyl ester (0.5g, 2.48mmol) in anhydrous THF (20mL) cooled to 0 C under nitrogen, LiAIH4 (104mg, 2.728mmol) was added. The reaction was allowed to warm to rt for 2 hrs. The reaction was cooled to 0 C and quenched with water (5mL). Potassium sodium tartrate ( ochelle’s salt) was added to help break up the suspension. The mixture was filtered through Celite, washing well with water (20mL) and ethyl acetate (lOOmL). The filtrate was collected and the layers separated. The aqueous extracted with ethyl acetate (3 x 20mL). The combined organic layers were washed with brine (50mL), dried over MgS04 and the solvent removed in vacuo. The crude was purified by flash chromatography (silica) eluting in step gradients up to 40% Pet. Ether, 60% ethyl acetate. Pure fractions were concentrated affording the title compound (6- chloro-5-methoxy-pyridin-3-yl)-methanol as a white solid (360mg, 2.074mmol, 84% yield). [M+H]+ = 174
According to the analysis of related databases, 915107-31-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; DAVIE, Rebecca Louise; EDWARDS, Hannah Joy; EVANS, David Michael; HODGSON, Simon Teanby; MILLER, Iain; NOVAK, Andrew Richard; SMITH, Alun John; STOCKS, Michael John; WO2014/188211; (2014); A1;,
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