Application of 120739-77-7 ,Some common heterocyclic compound, 120739-77-7, molecular formula is C8H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 100 mL three neck round bottom flask, 17.0 g (0.1 mol) of N-(6-chloropyridine-3-methylene)ethylamine, 15.0 g (0.09 mol) of 1,1-dimethylthio-2-nitroethylene, and 50 mL of absolute ethanol were added. Heated to reflux. Reflux for 8h. Stop reflow, cooled to room temperature. Concentrated to viscous liquid. Silica gel column chromatography (dichloromethane: acetone = 5: 1 (v / v)) gave the product 6.5 g (compound IV-1) in a yield of 23%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120739-77-7, its application will become more common.
Reference:
Patent; East China University of Science and Technology; Li, Zhong; Xu, Xiaoyong; Yuan, Zihao; Lu, Siyuan; Shao, Xusheng; Xu, Zhiping; (66 pag.)CN105669660; (2016); A;,
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