Reference of 1072438-56-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1072438-56-2, name is Methyl 6-(aminomethyl)nicotinate hydrochloride, molecular formula is C8H11ClN2O2, molecular weight is 202.6381, as common compound, the synthetic route is as follows.
Preparation 26Methyl 6-[(isobutyrylamino)methvHnicotinateTo an ice-cold suspension of methyl 6-(aminomethyl)nicotinate hydrochloride (1 .00 g, 4.1 8 mmol) and N-ethyl-N-isopropylpropan-2-amine (1 .89 g, 2.55 mL, 14.6 mmol) in DCM (10 mL) was added dropwise a solution of isobutyryl chloride (535 mg, 526 mu, 5.02 mmol) in DCM (3 mL). The reaction mixture was allowed to warm to room temperature, washed with water (5 mL), 1 0% aqueous citric acid solution (5 mL), saturated aqueous sodium bicarbonate solution (5 m L), brine (5 mL), dried over magnesium sulfate, filtered and evaporated to yield the title compound as a pale orange solid (0.988 g, 100%):1H NMR (400 MHz, CDCI3): delta 1 .22 (d, 6H), 2.45 – 2.55 (m, 1 H), 3.95 (s, 3H), 4.62 (d, 2H), 6.67 – 6.68 (br, 1 H), 7.32 – 7.36 (m, 1 H), 8.26 – 8.30 (m, 1 H), 9.15 (s, 1 H).LCMS Rt = 1 .72 minutes MS m/z 237 [MH]+
The chemical industry reduces the impact on the environment during synthesis 1072438-56-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER LIMITED; BROWN, Alan Daniel; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan; WO2012/7869; (2012); A2;,
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