Reference of 109306-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109306-86-7, name is 2-(2-Bromophenyl)pyridine, molecular formula is C11H8BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Process (i) A dry 50-mL two-necked round bottom flask equipped with a glass stopper and a three-way stopcock was charged with 2-(2-chlorophenyl)pyridine (1.20 g, 6.32mmol) and CH2Cl2 (10 mL). The resulting colorless solution was cooled to 0 C, and mCPBA (1.64 g, 9.50mmol) was added slowly. The temperature was gradually raised to rt, and the colorless solution was stirred for 6 h. Cooling again to 0 C, 1M aq NaOH (10 mL) was slowly added. The organic layer was washed with 1M aq NaOH (10 mL) and brine (10 mL), and then dried over Na2SO4 (10 g). Filtration followed by evaporation gave nearly pure 2-(2-chlorophenyl)-pyridine-N-oxide (1.28 g) as a yellow oil. This was used for the next reaction without further purification.
According to the analysis of related databases, 109306-86-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tanaka, Shinji; Suzuki, Yusuke; Kimura, Takahiro; Kitamura, Masato; Bulletin of the Chemical Society of Japan; vol. 92; 10; (2019); p. 1707 – 1720;,
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