Adding a certain compound to certain chemical reactions, such as: 175204-82-7, Methyl 4-(trifluoromethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H6F3NO2, blongs to pyridine-derivatives compound. Computed Properties of C8H6F3NO2
Step 1. To a stirred suspension of LAH (0.64 g, 17.0 mmol) in THF (30 mL) at -78 C. was added dropwise methyl 4-trifluoromethylnicotinate (1.74 g, 8.48 mmol) in THF (20 mL). The mixture was stirred for 1 h then carefully quenched with aqueous NaHCO3 (80 mL) and extracted with CH2 Cl2 (3*100 mL). The combined organic extracts were dried (Na2 SO4) and concentrated in vacuo to give 3-hydroxymethyl-4-trifluoromethylpyridine as an oil (TLC: Rf = 0.35 (1:1 hexane:EtOAc)).
The synthetic route of 175204-82-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck & Co., Inc.; US5756497; (1998); A;,
Pyridine – Wikipedia,
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