Related Products of 884495-01-6 ,Some common heterocyclic compound, 884495-01-6, molecular formula is C5H3BrFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-Bromo-2-ethoxy-5-fluoropyridine 2.08 mL (26.0 mmol) Ethyliodide and 1.08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500 mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo. C7H7BrFNO (M=220.0 g/mol) ESI-MS: 220 [M+H]+Rt (HPLC): 1.27 min (method X)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884495-01-6, its application will become more common.
Reference:
Patent; FLECK, Martin; NOSSE, Bernd; HEINE, Niklas; ROTH, Gerald Juergen; US2013/158004; (2013); A1;,
Pyridine – Wikipedia,
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