Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116855-08-4, name is 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below., Computed Properties of C7H5N3O2
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid (prepared according to the procedure in the literature; Lynch, B. M. et al, Can. J. Chem. 1988, 66, 420-428; 2 g, 9 mmol) was suspended in ethanol (60 mL) and purged with HCl gas for 5 min. The resultant mixture was stirred at room temperature overnight. The reaction mixture was concentrated, diluted with water, neutralized with 2M Na2CO3 solution, and extracted with ethyl acetate(3×20 mL). The combined organic layers were concentrated and the residue was purified by chromatography using 40-60% ethyl acetate/hexane as eluent to give ethyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate as light brown solid (904 mg, 40%). LC-MS; 228, [M+H]+.
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Reference:
Patent; Pfizer Inc.; US2011/28447; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem