18653-75-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18653-75-3, name is 2-(1H-Imidazol-2-yl)pyridine, molecular formula is C8H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 33 (1-33) A solution of iodine (6.99 g, 27.555 mmol) in DCM (29 mL) was added dropwise to a suspension of 2-(lH-imidazol-2-yl)pyridine (2g, 13.777 mmol) in NaOH (2M in water, 29 mL). The biphasic mixture was stirred vigorously at rt for 18 h. The aqueous layer was separated and neutralized with AcOH and then washed with sat. sol. Na2S203 was added until the solution remained colorless. The suspension was stirred for 10 min and the precipitate was filtered and dried in vacuo to yield 1-33 (4.45 g, 81%) as a solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18653-75-3, 2-(1H-Imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
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