With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.898746-42-4, name is 6-Fluoro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5FN2, molecular weight is 136.13, as common compound, the synthetic route is as follows.COA of Formula: C7H5FN2
Preparation 23Synthesis of l-ethy lo[2,3-b]pyridine.To a stirred solution of 6-fluoro-lH-pyrrolo[2,3-b]pyridine (15.00 g, 1 10.19 mmol) in DMF (100 mL), under a nitrogen atmosphere, is added potassium carbonate(22.84 g, 165.3 mmol), followed by ethyl bromide (12.36 mL, 165.3 mmol). The reaction is heated to 70 C for 4 h. Further ethyl bromide (3.00 mL, 27.6 mmol) is added and the reaction kept at 70 C overnight. After cooling further potassium carbonate (8.00 g, 57.9 mmol) and ethyl bromide (3.00 mL, 27.6 mmol) are added, and the reaction heated at 70 C for 4 h. The reaction is cooled, poured onto brine (ca. 500 mL) and the product extracted with CHCI3 (ca. 2 x 300 mL). The combined organic extracts are dried over magnesium sulphate, filtered, and concentrated in vacuo to give a brown oil. This is purified by column chromatography on silica, eluting with 0 to 70% DCM in hexane to give the title compound as a light yellow oil (16.38 g, 99.77 mmol). MS (m/z): 165 (M+l).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,898746-42-4, 6-Fluoro-1H-pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm; WO2012/74769; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem