Synthetic Route of 83393-46-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83393-46-8 as follows.
To a solution of 3-acetyl, 7-azaindole (320 mg, 2 mmol), thiohydantoin (465 mg, 3 mmol) and BF3.Et2O (1.52 mL, 12 mmol) in dry THF (14 mL), under argon, triethylamine (0.84 mL, 6 mmol) was added dropwise and the reaction mixture stirred for 5 days at RT. The mixture was poured in ice and pH made slightly basic by addition of sodium bicarbonate. The solution was extracted with ethyl acetate, dried over sodium sulfate and concentrated to give an oil that crystallized from ethyl acetate (260 mg, 1 mmol, 50% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83393-46-8, its application will become more common.
Reference:
Patent; Pharmacia Italia S.p.A.; US2007/112020; (2007); A1;,
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