A new synthetic route of 72141-44-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,72141-44-7, 4-Chloro-2-methoxypyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72141-44-7, name is 4-Chloro-2-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.5709, as common compound, the synthetic route is as follows.Safety of 4-Chloro-2-methoxypyridine

Step 1. Synthesis of 4-(biphenyl-2-yl)-2-methoxypyridine. A nitrogen flushed mixture of 4-chloro-2-methoxypyridine (3.0 g, 21.03 mmol), 2-biphenylboronic acid 5.0 g, 25.23 mmol), Pd2(dba)3 (381 mg, 0.414 mmol), 2-dicyclohexylphosphino-2′,6′- dimethoxybiphenyl (681 mg, 1.66 mmol), toluene (250 mL) and a slurry OfK3PO4H2O (14.57 g, 63.09 mmol) in water (25 mL) were refluxed for 18 h. After the mixture cooled to room temperature the organic layer was dried over anhydrous Na2SO4, filtered, and concentrated in vacuum. The residue was purified by flash chromatography on silica (hexane: ethyl acetate) and recrystallized from ethyl acetate to give 4-(biphenyl-2-yl)-2- methoxypyridine (4.2 g, 76.5%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,72141-44-7, 4-Chloro-2-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; MA, Bin; KWONG, Raymond, C.; WO2010/132524; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem