Synthetic Route of 1532517-95-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1532517-95-5, name is 5-Bromo-3-fluoro-2-nitropyridine, molecular formula is C5H2BrFN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: [00441] Step 2. To a solution of 200b (450 mg, 2.0 mmol, 1.0 eq) in DMF (5 mL) were added TEA (400 mg, 4.0 mmol, 2.0 eq) and 3-fluoroazetidine (300 mg, 4.0 mmol, 2.0 eq) at rt. The mixture was stirred for 2 h under N2 at 90 C and then diluted with EtOAc (200 mL). The mixture was washed with brine (3×100 mL), dried over Na2S04 and concentrated to give black oil, which was purified by reversed phase HPLC (MeCN/H20 = 2: 1) to give 200c (300 mg, 53%) as yellow oil. ESI-MS (M+H)+: 276.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1532517-95-5, 5-Bromo-3-fluoro-2-nitropyridine.
Reference:
Patent; BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.; WO2014/8214; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem