Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 851607-27-7, name is 5-Bromo-4-chloro-2-methoxypyridine. A new synthetic method of this compound is introduced below., Safety of 5-Bromo-4-chloro-2-methoxypyridine
Into a 30 mL sealed tube purged and maintained with an inert atmosphere of nitrogen, was placed 5-bromo-4-chloro-2-methoxypyridine (660 mg, 2.96 mmol, 1 eq), tert-butyl (2S)-2-methylpiperazine-l-carboxylate (1.2 g, 6 mmol, 2.02 eq), Pd2(dba) .CHCl (309 mg, 0.3 mmol, 0.10 eq), BINAP (372 mg, 0.60 mmol, 0.20 eq), t-BuONa (573 mg, 5.96 mmol, 2.01 eq) and toluene (4 mL). The resulting solution was stirred for 3 h at 95C in an oil bath. The crude mixture was concentrated and applied onto a silica gel column eluting with ethyl acetate/petroleum ether (1 :3). This resulted in 180 mg (18%) of tert-butyl (2S)-4-(4-chloro-6- methoxypyridin-3-yl)-2-methylpiperazine-l-carboxylate as yellow oil. LCMS: m/z = 342 [M+H]+.
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Reference:
Patent; PIPELINE THERAPEUTICS, INC.; XIONG, Yifeng; SCHRADER, Thomas; CHEN, Austin; ROPPE, Jeffrey Roger; BACCEI, Jill Melissa; BRAVO, Yalda; (199 pag.)WO2019/241131; (2019); A1;,
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