Adding a certain compound to certain chemical reactions, such as: 499-51-4, 4-Hydroxypyridine-2,6-dicarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4-Hydroxypyridine-2,6-dicarboxylic acid, blongs to pyridine-derivatives compound. Application In Synthesis of 4-Hydroxypyridine-2,6-dicarboxylic acid
Chelidamic acid (5 g, 27 mmol) was mixed with phosphorus pentabromide (58 g, 135 mmol) and heated to 80C for 2 h. The resulting mixture was cooled to room temperature, chloroform (50 ml_) was added and the mixture was filtered. The filtrate was cooled to 0C, methanol (90 ml_) was added in small portions and the resulting suspension was filtered off and dried under vacuum at 50C to afford dimethyl 4-bromopyridine-2,6-dicarboxylate (7 g, 93%). 1H NMR: dH (300 MHz, DMSO-d6) 8.43 (2H, s), 3.93 (6H, s).
The synthetic route of 499-51-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MIRONID LIMITED; ADAM, Julia Mary; ADAMS, David Roger; KULKARNI, Santosh Shripad; NANDURDIKAR, Rahul Shripad; (131 pag.)WO2019/193342; (2019); A1;,
Pyridine – Wikipedia,
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