Application of 64951-08-2, Adding some certain compound to certain chemical reactions, such as: 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64951-08-2.
Step (b) N-(2-aminoethyl)-N-{cis-4-[6-fluoro-2,4-dioxo-l-(tetrahydro-2H-thiopyran-4-yl)- l,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}imidazo[l,2-a]pyridine-2- carboxamide.; Imidazole[l,2a]pyridine-2-carboxylic acid (72 mg, 0.43 mmol) was dissolved in dry DMF (5 ml) and DIEA (0.2 ml, 1.15 mmol) was added, followed by HATU (164 mg, 0.43 mmol) and the mixture stirred for 10 min. (2-{4-[6-Fluoro-2,4-dioxo-l-(tetrahydro- thiopyran-4-yl)-l,4-dihydro-2H-pyrido[2,3-d]pyrimidin-3-yl]-cyclohexylamino}-ethyl)- carbamic acid tert-butyl ester (170 mg, 0.32 mmol) was added and the mixture stirred at room temperature overnight. The mixture was evaporated to dryness and the residue taken up into a mixture of TFA/Dichloromethane (1:1) (10 ml). Allowed to stand at room temperature for 2h. before being evaporated to dryness. The residue was dissolved in water (20 ml) and the solution was made basic by the addition of 0.88 aqueous ammonia solution. The solid that precipitated was collected by filtration then purified by reverse
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/84240; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem