Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Syntheses, kinetics and thermodynamics of BODIPY-based fluorescent probes with different kinds of hydrophilic groups for the detection of biothiols, the main research direction is BODIPY fluorescence probe biothiol.Formula: C6H9N.
A series of BODIPY-based fluorescent probes incorporating different kinds of hydrophilic groups were synthesized for the detection of biothiols (GSH as a representative target), namely BDP (control), BDP-OH (acidic), BDP-OEG (neutral and hydrophilic) and BDP-QA (cationic). The incorporation of nitroolefin unit (-CH=CH-NO2) to the BODIPY core enabled the OFF-ON fluorescent probes. The results indicated that the absorption and fluorescence emission spectra of the probes were essentially not affected by the hydrophilic groups attached on the para position of the meso Ph group. The reaction rate constants were affected by the hydrophilicity of probes. It was highly worth noting that the cationic BDP-QA had the fastest response toward biothiols owing to the best water solubility and the possible formation of ion pairs with thiolate (R-S-). Thermodn. illustrated that the reactions of probes with GSH all had neg. enthalpy changes and neg. entropy changes. Moreover, BDP-QA had the highest affinity toward GSH (K = 2.54 x 104 M-1) and the smallest LOD value (182 nΜ), which benefited from its best water solubility This work has primarily elucidated the effects of hydrophilic groups from the kinetic and thermodn. perspectives. It will promote better design of fluorescent probes with fast response and high affinity.
Here is a brief introduction to this compound(625-82-1)Formula: C6H9N, if you want to know about other compounds related to this compound(625-82-1), you can read my other articles.