Recommanded Product: 948552-36-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Synthesis and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents. Author is Shaik, Afzal B.; Bhandare, Richie R.; Nissankararao, Srinath; Lokesh, Bontha Venkata Subrahmanya; Shahanaaz, Shaik; Mukhlesur Rahman, M..
A series of chloropyrazine conjugated benzothiazepines I [Ar = Ph, 2-pyridyl, 3,4,5-tri-MeOC6H2, etc.] had been synthesized with 58%-95% yields. The compounds I were characterized by using different spectroscopic techniques including FT-IR, 1H NMR, 13C NMR spectroscopy and mass spectrometry. The synthesized compounds I and their precursor chalcones II were evaluated for antitubercular and cytotoxic activities. Addnl., compounds I were also tested for antimicrobial activity. Among the chalcone series II, compounds II [Ar = 3,4,5-tri-MeOC6H2, 2,4-di-ClC6H3] showed significant antitubercular activities (MICs 25.51 and 23.89μM, resp.), whereas among benzothiazepines, compounds I [Ar = 3,4,5-tri-MeOC6H2, 2,4-di-ClC6H3] displayed significant antimicrobial (MICs 38.02μM, 19.01μM) and antitubercular (MIC 18.10μ) activities. Compounds II [Ar = 3,4,5-tri-MeOC6H2, 2,4-di-ClC6H3] displayed cytotoxic activities with IC50 of 46.03 ± 1 and 35.10 ± 2μM resp. All the compounds I, II were evaluated for cytotoxic activity on normal human liver cell lines (L02) and found to be relatively less selective toward this cell line. The most active compounds I [Ar = 3,4,5-tri-MeOC6H2, 2,4-di-ClC6H3], II [Ar = 3,4,5-tri-MeOC6H2, 2,4-di-ClC6H3] identified through this study could be considered as potential leads for the development of drugs with possible antimicrobial, antitubercular and cytotoxic activities.
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