Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Inorganic Chemistry called Non-Macrocyclic Schiff Base Complexes of Iron(II) as ParaCEST Agents for MRI, Author is Scepaniak, Jeremiah J.; Kang, Eun Byoung; John, Michael; Kaminsky, Werner; Dechert, Sebastian; Meyer, Franc, which mentions a compound: 948552-36-1, SMILESS is O=CC1=CC=NN1, Molecular C4H4N2O, Application In Synthesis of 1H-Pyrazole-5-carbaldehyde.
Nearly two decades of research efforts were devoted to paramagnetic chem. exchange saturation transfer (paraCEST) to produce image contrast in magnetic resonance imaging. Less than twenty Fe-based paraCEST agents are reported so far, the majority of which are ligated by macrocyclic chelates. In the work presented here three isostructural tripodal ligands sharing a common tris-(aza-butenyl)amine foundation are explored to further diversify Fe-based paraCEST agents. One of the complexes provides contrast with a CEST effect of 33% for a 10 mΜ sample, a paramagnetic shift (Δω) of 85 ppm from bulk H2O, and exhibits some stability to biol. relevant ions.
There is still a lot of research devoted to this compound(SMILES：O=CC1=CC=NN1)Application In Synthesis of 1H-Pyrazole-5-carbaldehyde, and with the development of science, more effects of this compound(948552-36-1) can be discovered.