With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54189-82-1, name is 6-Chloro-N-methylnicotinamide, molecular formula is C7H7ClN2O, molecular weight is 170.6, as common compound, the synthetic route is as follows.category: pyridine-derivatives
6-({2-[(2/?,5/?)-2>5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-yl}oxy)-yV-methyl- 3-pyridinecarboxamide (E9) Sodium hydride (22mg, 0.55mmol, 60% in mineral oil) was added to a solution of 2-[(2f?,5R)-2,5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-ol (may be prepared as described in Description 8) (105mg, 0.45mmol) in dimethylformamide (4ml) and the resulting mixture was stirred at room temperature for 20 minutes. 6-Chloro-Lambda/-methyl-3- pyridinecarboxamide (93mg, 0.55mmol; may be prepared as described in Description 10 of WO2004056369) was added and the mixture heated at 9O0C under argon for 21 hours. The mixture was then cooled to room temperature, applied to an sex ion exchange column and eluted with methanol and then a solution of ammonia in methanol (2M). The basic fractions were evaporated under reduced pressure and the residue purified on the mass directed autoprep to afford the title compound (E9); MS (ES+) m/e 366 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/61193; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem