In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug-Resistant Staphylococcus aureus, published in 2020-02-29, which mentions a compound: 50816-19-8, mainly applied to hexadecynoate isomer structure antibacterial activity Staphylococcus; Alkynoic fatty acids; Ciprofloxacin-resistant S. aureus; Critical micelle concentration; DNA gyrase; MRSA; Susceptibility tests, Computed Properties of C8H17BrO.
the structural characteristics that impart antibacterial activity to C16 alkynoic fatty acids (aFA) were further investigated. The syntheses of hexadecynoic acids (HDA) containing triple bonds at C-3, C-6, C-8, C-9, C-10, and C-12 were carried out in 4 steps and with an overall yield of 34-78%. In addition, HDA analogs containing a sulfur atom at either C-4 or C-5 were also prepared in 69-77% overall yields, resp. the triple bond at C-2 is pivotal for the antibacterial activity displayed by 2-HDA, while the farther the position of the triple bond from the carbonyl group, the lower its bactericidal activity against gram-pos. bacteria, including clin. isolates of methicillin-resistant Staphylococcus aureus (CIMRSA) strains. The potential of 2-HDA as an antibacterial agent was also assessed in 5 CIMRSA strains that were resistant to Ciprofloxacin (Cipro) demonstrating that 2-HDA was the most effective treatment in inhibiting their growth when compared with either Cipro alone or equimolar combinations of Cipro and 2-HDA. Moreover, it was proved that the inhibition of S. aureus DNA gyrase can be linked to the antibacterial activity displayed by 2-HDA. Finally, it was determined that the ability of HDA analogs to form micelles can be linked to their decreased activity against gram-pos. bacteria, since critical micellar concentrations of 50-300 μg/mL were obtained.
Compound(50816-19-8)Computed Properties of C8H17BrO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(8-Bromooctan-1-ol), if you are interested, you can check out my other related articles.