Formula: C6H9N. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Construction of a red emission BODIPY-based probe for tracing lysosomal viscosity changes in culture cells. Author is Shen, Baoxing; Wang, Ling Feng; Zhi, Xu; Qian, Ying.
A red emission boron-dipyrromethene based lysosome-targeted viscosity probe was synthesized for monitoring lysosomal viscosity in live cells. The increase of viscosity can restrict the twisting of double bond between indole and boron-dipyrromethene fluorophore, also restrict the rotating of single bond between quinoline and boron-dipyrromethene, which lead to the enhancement of fluorescence intensity in high viscosity environment. The changes of fluorescence intensity exhibit a good linear relationship with viscosity values. Besides, lysosome-targeted viscosity probe is quite stable in various pH solvents with given viscosity, suggesting that lysosome-targeted viscosity probe is suitable for applying in a wide pH range. Moreover, lysosome-targeted viscosity probe can visualize the changes of lysosomal viscosity in live cells under the stimulus of dexamethasone. Bovine serum albumin titration experiment demonstrated that lysosome-targeted viscosity probe is stable in the presence of macromols. and proteins. Notably, the fluorescence lifetime of lysosome-targeted viscosity probe in large viscosity solvents is extremely high. These results indicate that lysosome-targeted viscosity probe is an excellent tool for detecing viscosity changes in vitro and live cells.
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