Odani, Riko; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro published the article 《Copper-Mediated Dehydrogenative Biaryl Coupling of Naphthylamines and 1,3-Azoles》. Keywords: dehydrogenative regioselective cross coupling naphthylamine azole picolinamide directing group; copper catalyst dehydrogenative regioselective cross coupling naphthylamine azole.They researched the compound: Picolinoyl chloride hydrochloride( cas:39901-94-5 ).Application of 39901-94-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:39901-94-5) here.
A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of an N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds smoothly without precious transition metal catalysts and provides highly π-extended heterobiaryls directly. E.g., in presence of Cu(OAc)2 and pivalic acid in mesitylene, dehydrogenative cross-coupling of N-(2-pyridylcarbonyl)-substituted 2-naphthylamine (I) with benzoxazole gave 73% II.
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