Wang, Lingfeng; Qian, Ying published the article 《Near-infrared quinoline-fluoroborodipyrrole dye: synthesis and lysosomal fluorescence imaging》. Keywords: near IR quinoline fluoroborodipyrrole dye lysosomal fluorescent imaging synthesis.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).SDS of cas: 625-82-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.
A near-IR region (NIR) fluoroborodipyrrole fluorescent dye (QBOP-lys) was synthesized through Knoevenagel condensation reaction. The D-A configuration of the QBOP-lys dyes was conjugated by two p-morpholine styrene with one 8-hydroxyquino BODIPY structure. This QBOP-lys dye has been characterized by NMR and high resolution mass spectrometry. In DMSO (DMSO) solution, the maximum absorption wavelength of QBOP-lys was at 698 nm and its molar extinction coefficient was 5.9×104 L·mol-1·cm-1, the maximum emission wavelength was at 770 nm and its stokes shift was 73 nm. Besides that, QBOP-lys has been prepared as water-soluble nano-silica fluorescent nanoparticles (QBOP-lys/SiO2). The maximum emission wavelength of QBOP-lys/SiO2 was 726 nm in pure aqueous solution and the fluorescence quantum of QBOP-lys/SiO2 was 0.33, which made QBOP-lys have good near-IR fluorescence emission characteristics in organic solvents or pure water. On the other hand, QBOP-lys was also used for lysosomal imaging in SGC-7901 cells, the colocalization coefficient of dye QBOP-lys with Lyso-Tracker Green, a com. lysosomal green dye, was up to 0.9. Besides that, after QBOP-lys incubate with cells SGC-7901 for 48 h, it could still maintain good fluorescence imaging performance which could be used for long-term tracking imaging. The spectroscopy experiments and cell experiments both proved that dye QBOP-lys was a very promising NIR dye in future application.
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