In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging, published in 2021-12-31, which mentions a compound: 625-82-1, mainly applied to meso paracyclophanyl BODIPY dye NIR imaging aggregation, Recommanded Product: 2,4-Dimethyl-1H-pyrrole.
J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-IR window. However, the design of the second near-IR fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-IR fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophys. properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clin. application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-IR imaging agents.
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