Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1173081-96-3, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1173081-96-3
To a stirred solution of 5-bromo-3-(sec-butyl(methyl)amino )-2-methylbenzoic acid(500 mg, 1.666 mmol), EDC (479 mg, 2.498 mmol), and HOBT (383 mg, 2.498 mmol) indimethyl sulfoxide (DMSO) (40 mL) was added N-methylmorpholine (0.732 mL, 6.66mmol), followed by 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one hydrochloride (377mg, 1.999 mmol). The reaction mixture was stirred at 25 oc for 16 h. The reaction mixture was poured onto ice water (50 mL), stirred for 10 min, allowed to stand for 10 min, andthen filtered. The collected solid was rinsed with water (50 mL), followed by 10%MeOH/ice water (50 mL) and diethyl ether (25 mL). The contents were filtered and dried to afford 400 mg of crude product. The product was purified by silica gel chromatography(eluent: 100% EtOAc) to afford the title compound (200 mg, 27% yield) as an off-whitesolid. 1H NMR (400 MHz, DMSO-d6) 8 ppm 0.83 (t, 3H, J = 7.5 Hz), 0.96 (d, 3H, J = 6.4Hz), 1.41-1.49 (m, 1H), 1.51-1.57 (m, 1H), 2.11 (s, 6H), 2.18 (s, 3H), 2.53 (s, 3H), 2.90-2.96 (m, 1H), 4.23 (d, 2H, J = 4.9 Hz), 5.85 (s, 1H), 6.99 (s, 1H), 7.14 (s, 1H), 8.17 (t, 1H,J = 4.9 Hz), 11.5 (s, 1H). LCMS(ES) [M+Ht 434.5.
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Reference:
Patent; GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar; WO2013/173441; (2013); A2;,
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