HPLC of Formula: 948552-36-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new neodymium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi.
Neodymium(III) complexes with methylenebis(coumarins) I (R = Ph, 2-pyridyl, 4-pyridyl, 3-pyrazolyl) were synthesized by reaction of Nd(III) salt and the ligands in metal:ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Nd(III) salt to an aqueous solution of the ligand and subsequently raising the pH of the mixture gradually to ∼5.0 by adding a dilute solution of NaOH. The Nd(III) complexes with bis-coumarins were characterized by different physicochem. methods: elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of the Nd(III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Nd(III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C:O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The complexes were tested on HL-60, HL-60/Dox and lymphoid SKW-3 cell lines. The overall results from the preliminary screening program revealed that all of the new Nd(III) complexes reach 50% inhibition of the malignant cells proliferation and thus could be considered as biol. active. From the IC50 values obtained, compounds Nd(L1)(OH)·H2O and Nd(L3)(OH)·2H2O exert superior activity in comparison to the remaining complexes.
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