Share a compound : Application of 175461-33-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175461-33-3, its application will become more common.

Application of 175461-33-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 175461-33-3 as follows.

Sulfuric acid (60 mL) was cooled to 0 0C and (2,6-dichloro-pyridin-4-yl)- methylamine (11.9 g, 62.51 mmol) was added. Nitric acid (2.59 mL, 62.51 mmol) was added dropwise. The resulting yellow solution was stirred at 00C for 1 hour. The reaction mixture was poured into ice water (600 ml_). Ethyl acetate was added and the phases separated. The aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with aqueous sodium carbonate, dried over magnesium sulphate, filtrated and evaporated to give a yellow solid. The solid was redissolved in sulfuric acid poured into ice water (500 ml_). The resulting solid was filtered off and washed with water to give (2,6-dichloro-3-nitro-pyridin-4-yl)-methyl- amine (10.5 g, 76%) as a yellow crystalline compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175461-33-3, its application will become more common.

Reference:
Patent; NeuroSearch A/S; WO2008/92942; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem