Safety of Picolinoyl chloride hydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Discovery, Synthesis, and Structure-Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model. Author is Jones, Carrie K.; Engers, Darren W.; Thompson, Analisa D.; Field, Julie R.; Blobaum, Anna L.; Lindsley, Stacey R.; Zhou, Ya; Gogliotti, Rocco D.; Jadhav, Satyawan; Zamorano, Rocio; Bogenpohl, Jim; Smith, Yoland; Morrison, Ryan; Daniels, J. Scott; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R..
An increasing amount of studies on selective pos. allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) showed their pos. effects on preclin. antiparkinsonian rodent models; however, these compounds have not been optimized for druglike properties, and as the result, exhibited poor pharmacokinetic properties. Herein, synthesis and biol. evaluation of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenyl picolinamides with improved PK properties with excellent potency and selectivity as well as improved brain exposure in rodents are reported. Finally, amide I (ML182) was shown to be orally active in the haloperidol induced catalepsy model, a well-established antiparkinsonian model.
Although many compounds look similar to this compound(39901-94-5)Safety of Picolinoyl chloride hydrochloride, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=NC=CC=C1.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.