In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and photophysical properties of tumor-targeted water-soluble BODIPY photosensitizers for photodynamic therapy, published in 2020, which mentions a compound: 625-82-1, mainly applied to BODIPY photosensitizer photophys property photodynamic therapy antitumor; BODIPY; click reaction; lactose; photodynamic therapy; photosensitizer, Safety of 2,4-Dimethyl-1H-pyrrole.
The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-sindacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on three distinct cancer cell lines (human hepatoma Huh7, cervical cancer HeLa, and breast cancer MCF-7 cell lines). The halogenated BODIPY dyes exhibited a decreased fluorescence quantum yield compared to their non-halogenated counterpart, and facilitated the efficient generation of singlet oxygen species. The synthesized dyes exhibited low cytotoxicities in the dark and high photodynamic therapeutic capabilities against the treated cancer cell lines following irradiation at 530 nm. Moreover, the incorporation of lactose moieties led to an enhanced cellular uptake of the BODIPY dyes. Collectively, the results presented herein provide promising insights for the development of photodynamic therapeutic agents for cancer treatment.
Although many compounds look similar to this compound(625-82-1)Safety of 2,4-Dimethyl-1H-pyrrole, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.