In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Spiroazetidine-piperidine bromoindane as a key modular template to access a variety of compounds via C-C and C-N bond-forming reactions, published in 2012-11-21, which mentions a compound: 894086-00-1, mainly applied to palladium catalyst borylation Suzuki coupling spiroazetidine piperidine bromoindan, Electric Literature of C32H35N4P.
In the context of our ghrelin inverse agonist program, a functionalized bromoindane I provided a versatile intermediate for structure-activity relationship studies. After developing operationally simple cross-coupling reactions, a broad spectrum of chem. space was successfully explored. Optimization of a one-pot borylation/Suzuki sequence provided the desired products in high yield with low loading of the palladium catalyst. High yields of N-linked heterocyclic analogs were obtained through palladium catalyzed C-N bond formation. In addition, carboxylation of the bromoindane provided an indane carboxylic acid for further diversification.
After consulting a lot of data, we found that this compound(894086-00-1)Electric Literature of C32H35N4P can be used in many types of reactions. And in most cases, this compound has more advantages.