Electric Literature of 15862-37-0, Adding some certain compound to certain chemical reactions, such as: 15862-37-0, name is 2,5-Dibromo-3-nitropyridine,molecular formula is C5H2Br2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15862-37-0.
To a solution of 2,5-dibromo-3-nitropyridine (5.00 g, 17.8 mmol) in EtOH (20 mL), water (27 mL) and toluene (30 mL) was added thiophen-3 -ylboronic acid (2.39 g, 18.7 mol) and Na2CO3 (5.68 g, 53.6 mol) under N2. The mixture was purged with N2 for 2 mm and followed by addition of tetrakis(triphenylphosphine)palladium (1.04 g, 0.900 mmol). The reaction mixture was heated to reflux for 16 h. Then the reaction mixture was cooled to r.t.and extracted with EtOAc (100 mL). The collected organic phase was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography using 0-5% EtOAc in hexane to afford the title compound (3.84 g, 76% yield) as a light yellow solid. LC-MS [M+H]= 286.
According to the analysis of related databases, 15862-37-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JACOBIO-BETA PHARMACEUTICALS CO., LTD.; JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.; JACOBIO PHARMACEUTICALS CO., LTD.; FANG, Haiquan; ZHOU, Wenlai; HU, Shaojing; CHEN, Mingming; YANG, Guiqun; WANG, Yanping; DU, Yuelei; LI, Qinglong; WU, Tong; WU, Lingjun; LI, Haijun; LONG, Wei; (179 pag.)WO2019/80941; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem