So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hoffelner, Michael; Petritsch, Markus; Ahmad, Sarfraz; Seebacher, Werner; Dolensky, Johanna; Hochegger, Patrick; Kaiser, Marcel; Maeser, Pascal; Saf, Robert; Weis, Robert researched the compound: Picolinoyl chloride hydrochloride( cas:39901-94-5 ).Related Products of 39901-94-5.They published the article 《New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities》 about this compound( cas:39901-94-5 ) in Monatshefte fuer Chemie. Keywords: azabicyclononane derivative preparation SAR antiplasmodial antitrypanosomal. We’ll tell you more about this compound (cas:39901-94-5).
New derivatives of 3-azabicyclo[3.2.2]nonanes such as I [R = pyridin-2-yl, pyridin-3-yl, pyridin-4-yl] were prepared and characterized using FT-IR spectroscopy, HRMS, and NMR spectroscopy. The new compounds were investigated in vitro for their antiplasmodial activities against sensitive NF54 strain and multiresistant K1 strain of Plasmodium falciparum, and for their antitrypanosomal activity against Trypanosoma brucei rhodesiense. Compound I [R = pyridin-4-yl] possessed high antiplasmodial in vitro activity against both strains of P. falciparum (NF54: IC50 = 0.848 nm; K1: IC50 = 2 nm). The most promising ones were further investigated in a mouse model for their in vivo activity against Plasmodium berghei.
Different reactions of this compound(Picolinoyl chloride hydrochloride)Related Products of 39901-94-5 require different conditions, so the reaction conditions are very important.