Safety of (6-Fluoropyridin-3-yl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (6-Fluoropyridin-3-yl)methanol, is researched, Molecular C6H6FNO, CAS is 39891-05-9, about Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent. Author is Pesti, Jaan A.; Huhn, George F.; Yin, Jianguo; Xing, Yide; Fortunak, Joseph M.; Earl, Richard A..
2-Fluoro-4-methylpyridine is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 2-Fluoro-4-methanesulfonylmethylpyridine. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the title compound, a cognition enhancer drug candidate. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis. The chlorination of other methylpyridines was also investigated.
《Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((6-Fluoropyridin-3-yl)methanol)Safety of (6-Fluoropyridin-3-yl)methanol.