Application of 329-89-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Aminonicotinamide, is researched, Molecular C6H7N3O, CAS is 329-89-5, about Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy. Author is Nakayama, Taku; Hikawa, Hidemasa; Kikkawa, Shoko; Azumaya, Isao.
A synthetic method for dehydrative N-benzylation promoted by water mols. in heptane using a π-benzylpalladium system has been developed. The presence of water significantly accelerates carbon-nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding N-monobenzylated products. A crossover experiment afforded H/D scrambled products, which is consistent with a borrowing hydrogen mechanism. Kinetic isotope effect measurements revealed that benzylic carbon-hydrogen bond cleavage was the rate-determining step.
This compound(6-Aminonicotinamide)Application of 329-89-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.