Adding a certain compound to certain chemical reactions, such as: 627501-18-2, 5-Chloro-6-hydroxynicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde
General procedure: Unless otherwise stated, the procedure was as follows. To a 1-dram (4 mL) vial equipped with a magnetic stir bar were added Pd(OAc)2 (4.4 mg, 0.02 mmol), alkene (0.2 mmol), acetic acid (6.0 mg, 0.1 mmol), nucleophile (0.3 mmol), and MeCN (0.1 mL). The vial was sealed with an unpunctured TFE septum-covered screw cap, and placed in a heating block that was pre-heated to 120 C. After the designated reaction time, the dark black reaction was purified either by flash column chromatography only or by flash column chromatography followed by an aqueous workup to produce the desired product.
The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gurak, John A.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M.; Tetrahedron; vol. 73; 26; (2017); p. 3636 – 3642;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem