In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108118-69-0, name is 2,6-Difluoropyridin-3-amine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives
To a stirred solution of 1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-6]pyridine-5-carboxylic acid (47 mg, 0.17 mmol) in CH2C12 (2 mL) was added l-chloro-N,N-2-trimethylpropenylamine (45 muL, 0.34 mmol). Following formation of the resulting acid chloride, the reaction mixture was concentrated affording a residue that was dissolved in pyridine (2 mL) before 2,6-difiuoro- pyridin-3-ylamine (20 mg, 0.15 mmol) was added in one portion. After an additional 30 minutes the reaction mixture was concentrated to dryness affording a residue, to which was added DMF (2 mL) and K2CO3 (64 mg, 0.46 mmol). The resulting mixture was heated by microwave to 150 ºC for 10 min, after which the resulting mixture was filtered and concentrated, affording 5- fluoro-2-[ 1 -(4-methoxy-benzyl)-1H-pyrroIo[2,3-b]rhoyridin-5-yl]-oxazolo[5,4-^]pyridine as a crude residue which was subsequently used without further purification. ES MS (M+H+) = 375.
The synthetic route of 108118-69-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2009/155017; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem