Synthetic Route of 166266-19-9 ,Some common heterocyclic compound, 166266-19-9, molecular formula is C6H7IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 50 mL resealable tube, a solution of 4-bromothiophenol (3.2 g, 17 mmol, Sigma- Aldrich, India) and 5-iodo-3-methyl-2-pyridinamine (2 g , 8.5 mmol) in DMSO (20 mL) was degassed by purging with argon gas at room temperature for 10 min. Potassium carbonate (3.53 g, 25.6 mmol) and cooper iodide (0.2 g ,1.1 mmol) were added sequentially to the above reaction mixture at room temperature under argon atmosphere The reaction tube was sealed under argon atmosphere and reaction mixture was heated at 150 C for 18 h. The reaction mixture was cooled to room temperature and filtered through a Celite (diatomaceous earth) pad. The filtrate was diluted with cold water (200 mL) and ethyl acetate (100 mL). The EtOAc layer was separated, washed with water, brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue obtained was purified by silica gel (60 to 120 mesh) column chromatography (eluent, 20% EtOAc-hexanes) to give 5-((4- bromophenyl)sulfanyl)-3-methyl-2-pyridinamine (2.7 g) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,166266-19-9, its application will become more common.
Reference:
Patent; AMGEN INC.; ASHTON, Kate; BOURBEAU, Matthew, Paul; HONG, Fang-Tsao; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; POON, Steve, F.; STEC, Markian, M.; ST. JEAN, David, J., JR; TAMAYO, Nuria, A.; YANG, Kevin, C.; WO2013/123444; (2013); A1;,
Pyridine – Wikipedia,
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