Reference of 884494-45-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 884494-45-5, name is 2-Fluoro-4-iodo-6-methylpyridine. A new synthetic method of this compound is introduced below.
INTERMEDIATE 25 4-lodo-2-methvl-6-(propan-2-vloxv)pyridine A mixture of 2-fuoro-4-iodo-6-methylpyridine (0.20 g, 0.84 mmol), isopropanol (0.20 mL, 2.6 mmol) and sodium hydride (95%, 100 mg, 4.0 mmol) in diethyl ether (5 mL) was stirred at 23 C for 16 h. The reaction mixture was filtered through a plug of silica gel, eluting with diethyl ether, and the solvent was allowed to evaporate at atmospheric pressure to give the 78 title compound. MS: m/z = 278.2 (M + 1). 1H NMR (400 MHz, DMSO) 6 7.20 (dd, 1H, J = 1.2, 0.7 Hz), 6.96 (dd, 1H, J = 1.3, 0.7 Hz), 5.26-5.15 (m, 1H), 2.32 (s, 3H), 1.25 (d, 6H, J = 6.2 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-45-5, 2-Fluoro-4-iodo-6-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BELL, Ian, M.; ZHAO, Lianyun; FRALEY, Mark; ZHU, Cheng; BIFTU, Tesfaye; BRNARDIC, Edward Joseph; WANG, Cheng; ZARTMAN, C. Blair; GALLICCHIO, Steven; NGUYEN, Diem; CROWLEY, Brendan; POTTEIGER, Craig; (257 pag.)WO2016/22644; (2016); A1;,
Pyridine – Wikipedia,
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