Application of 185041-05-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.185041-05-8, name is Methyl 2-chloro-4-iodonicotinate, molecular formula is C7H5ClINO2, molecular weight is 297.48, as common compound, the synthetic route is as follows.
Amixture of methyl 2-chloro-4-iodonicotinate (4.00 g, 13.5 mmol, prepared inStep 1 for 23),(2,5-difluorophenyl)boronic acid (2.19 g, 13.8 mmol), PdCl2(dppf)(0.984 g, 1.34 mmol) and K2CO3 (4.65 g, 33.6 mmol) indioxane (25 mL) and water (5 mL) was heated to 80 C and stirred for 12 h. Thereaction mixture was filtered to remove insoluble material. The filtrate wasdiluted with water (55 mL) and the mixture was extracted with EtOAc (2 x 30mL). The combined organic phase was washed with brine (40 mL), dried withanhydrous Na2SO4, filtered and concentrated invacuo. The residue was purified by flash column chromatography on silicagel (Petroleum ether/EtOAc = 100/1 to 30/1) to afford methyl2-chloro-4-(2,5-difluorophenyl)nicotinate (3.70 g, 87%) as a colorless oil. 1HNMR (400 MHz, CDCl3) delta 3.78 (3H, s), 7.00-7.07 (1H, m), 7.09-7.19(2H, m), 7.30 (1H, d, J = 5.2 Hz),8.52 (1H, d, J = 5.2 Hz). MS (ESI)m/z: 284.0 [M+H]+.
Statistics shows that 185041-05-8 is playing an increasingly important role. we look forward to future research findings about Methyl 2-chloro-4-iodonicotinate.
Reference:
Article; Miyazaki, Tohru; Kawasaki, Masanori; Suzuki, Atsushi; Ito, Yuki; Imanishi, Akio; Maru, Takamitsu; Kawamoto, Tomohiro; Koike, Tatsuki; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 815 – 820;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem