Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 896139-85-8
To a solution of imidazo[l,2-a]pyridin-7-ol (CAS 896139-85-8; 100 mg, 0.745 mmol) in dry DMF (4 mL) are added ethyl 2-bromo-2-methyl-propanoate (CAS 600-00-0; 444 pL, 2.98 mmol) and K2CO3 (412 mg, 2.98 mmol). The mixture is stirred at 60 C for 6 h. The reaction medium is diluted with water and extracted with DCM. Organic layers are combined, dried over Na2S04, filtered and concentrated. The crude material is purified by chromatography on silica gel (eluting with a gradient of 0 to 10% MeOH in DCM) to afford Int 67.
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Reference:
Patent; GALAPAGOS NV; DESROY, Nicolas; JONCOUR, Agnes, Marie; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; BUCHER, Denis; AMANTINI, David; DE VOS, Steve, Irma, Joel; BRYS, Reginald, Christophe, Xavier; (396 pag.)WO2019/238424; (2019); A1;,
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