Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7477-10-3, name is 6-Chloro-5-nitronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H3ClN2O4
[00190] To a stirred solution of 6-chloro-5-nitro-pyridine-3-carboxylic acid (500 mg, 2.46 mmol) in dioxane (5 mL) was added tert-butyl N-[(E)-4-aminobut- 2-enyl]carbamate hydrochloride (500 mg, 2.71 mmol) followed by DIPEA (1.09 mL, 6.27 mmol); mixture was stirred at RT overnight. The mixture was diluted with water and acidified to pH ~3 with 3 N HCI. The resulting suspension was filtered to give the desired product as a yellow solid, dried in oven (636 mg, 73%). 1H NMR (de-DMSO) d 13.20 (brs, 1H), 9.00 (t, J = 6 Hz, 1H), 8.89 (d, J = 4 Hz, 1H), 8.74 (d, J = 4 Hz, 1H), 6.99-6.91 (m, 1H), 5.72-5.53 (m, 2H), 4.27- 4.18 (m, 2H), 3.56-3.47 (m, 2H), 1.36 (s, 9H).
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Reference:
Patent; TRILLIUM THERAPEUTICS INC.; SLASSI, Abdelmalik; DOVE, Peter; ROSA, David Alexander; WANG, Zezhou; WINSTON, Jeffrey Todd; LIN, Hoi Ying; (0 pag.)WO2020/10451; (2020); A1;,
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