Related Products of 944317-27-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine. A new synthetic method of this compound is introduced below.
6-Bromo-3-chloro-2-methylpyridine (1.07 g), Pd(dppf)Cl2 DCM (423 mg) and triethylamine (524 mg) were stirred in a mixed solution of methanol (7.5 mL) and DMF (7.5 mL) in the presence of carbon monoxide (3 atm) at 90C for 3 hr. The solvent of the reaction mixture was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (724 mg). MS (ESI+) : [M+H]+185.9.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,944317-27-5, 6-Bromo-3-chloro-2-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; KIMURA, Eiji; SUZUKI, Shinkichi; ASHIZAWA, Tomoko; IMAEDA, Toshihiro; FUJIMORI, Ikuo; ARAI, Ryosuke; (82 pag.)EP3156397; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem