Reference of 54453-93-9 , The common heterocyclic compound, 54453-93-9, name is Ethyl 2-Chloropyridine-4-carboxylate, molecular formula is C8H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: For the synthesis of substituted benzoylhydrazines, a mixture of corresponding esters (20 mmol), 85% hydrazine hydrate (20 mmol) in ethanol (35 ml) was heated to reflux for 5 h. After that, the solution was poured into ice-water. The precipitate was filtered and crystallized from ethanol.
The synthetic route of 54453-93-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Kai; Lu, Xiang; Zhang, Hong-Jia; Sun, Juan; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 47; 1; (2012); p. 473 – 478;,
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