Reference of 34486-24-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 34486-24-3 as follows.
To a solution of 6-trifluoromethyl-pyridin-2-ylamine (10.0 g, 62.1 mmol, 1 eq) in CHCI3 (200 mL) was added NBS (12.0 g, 67.4 mmol, 1.08 eq). The solution was stirred in the dark for 2 h, at which time it was added to DCM (200 mL) and 1 N NaOH (200 mL). Upon mixing, the layers were separated and the organic layer was dried and concentrated. The residue was purified by silica gel column (EA/PE = 1/1, v/v) to give 5-bromo-6- trifluoromethyl-pyridin-2-ylamine (6.5 g, 44%) as an orange solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34486-24-3, its application will become more common.
Reference:
Patent; LIFESCI PHARMACEUTICALS, INC; MCDONALD, Andrew; QIAN, Shawn; (100 pag.)WO2017/1926; (2017); A2;,
Pyridine – Wikipedia,
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