Related Products of 940911-03-5 ,Some common heterocyclic compound, 940911-03-5, molecular formula is C8H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
C . 5 – { [4-(5 ,5 -Dimethyl- 1 ,3 ,2-dioxaborinan-2-yl)phenyl] ethynyl} pyridine -2- carbaldehyde; To an argon purged solution of 2-(4-iodophenyl)-5,5-dimethyl-l,3,2- dioxaborinane (Method 3, step A) (15 g, 48 mmol) in acetonitrile was addedPdCl2(PPh3)2 (0.7 g, 9.5 mmol) and CuI (0.09 g, 4.7 mmol) at room temperature. The resulting solution was stirred under argon for 10 min. Triethylamine (20 mL, 142 mmol) followed by 5-[(trimethylsilyl)ethynyl]pyridine-2-carbaldehyde (8.1 g, 62mmol) were added and the reaction mixture was then stirred at 85 0C for 2 h. The reaction mixture was concentrated under reduced pressure and then ice-cold water was added. The precipitated solid was stirred as a suspension and was then filtered and washed with water followed by pet-ether to provide 5-{[4-(5,5-dimethyl-l,3,2-dioxaborinan-2- yl)phenyl]ethynyl}pyridine-2-carbaldehyde (15 g, 99%) as brown solid. LC-MS: [M+H]+ 3201H NMR (400 MHz, CDCl3) delta: ppm 10.08 (s, IH), 8.89 (s, IH), 7.95 (m, 2H), 7.82 (d, 2H), 7.55 (d, 2H), 3.78 (s, 4H), 1.03 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,940911-03-5, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew; WO2010/100475; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem