The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 832735-60-1, name is 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4BrN3
To a suspension of 7-bromo-[l,2,4]triazolo[4,3-a]pyridine (930.9 mg, 4.70 mmol) and diphenylmethanimine (1.70 g, 9.38 mmol) in toluene (40 mL) were added Pd2(dba)3 (217.7 mg, 0.24 mmol), BINAP (293.4 mg, 0.45 mmol) and t-BuONa (908.4 mg, 9.45 mmol). The reaction mixture was stirred at 100 C overnight and quenched with water (50 mL), and the resulting mixture was extracted with EtOAc (100 mL x 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/20) to give the title compound as a brown solid (1.66 g, yield 46.3%).MS (ESI, pos. ion) m/z: 299.2 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 832735-60-1.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridine – Wikipedia,
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